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Back Issues  —  2008

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[Around the World]
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[What's Your Diagnosis?]
[Zoonotic Infections]

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AROUND THE WORLD
Fake antimalarial drugs abound in endemic Asian countries May 2008: Experts fear patients could die from counterfeit antimalarial drugs manufactured by sophisticated criminals in huge drug market.
Chikungunya epidemic in India may have been underreported March 2008: Inaccuracies in reporting possibly underplayed the mortality rates associated with the chikungunya epidemic.

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BREAKING NEWS
ACIP expands influenza vaccine recommendations March 2008: Previous recommendation was for children aged between 6 and 59 months.
New drugs, trials lead to updated IDSA aspergillosis treatment guidelines February 2008: New guidelines stress the need for early, effective antifungal therapy.
USA300 MRSA may be sexually transmitted in MSM February 2008: Male–male sex should be considered a risk factor for multidrug-resistant USA300 MRSA infection, independent of previous infection.
Foodborne illness an escalating concern January 2008: The annual number of foodborne illness cases in the United States reaches about 76 million.

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EMERGING DISEASES
Globalization impacts food safety standards in the United States July 2008: Multifaceted strategies may be necessary to combat the increased risks.
IDSA updates treatment recommendations for blastomycosis July 2008: Amphotericin B recommended as primary therapy for more serious blastomycosis.
Human Microbiome Project will improve knowledge about microbes’ effects on human health July 2008: Comprehensive study of microbial communities may lead to sweeping discoveries.
NIAID outlines agenda for TB research July 2008: MDR and XDR strains require focus.
TB reemerging in Europe July 2008: Recent data indicate TB may be more widespread than many people believe.
Connecticut attorney general, IDSA settle Lyme disease case June 2008: As part of the settlement, the IDSA will conduct a new review of the Lyme disease guidelines.
Campylobacter outbreak among mountain bikers linked to mud May 2008
Multiple factors led to mumps outbreak in Midwest May 2008
Acute hepatitis immunization program successful in Italy April 2008: Fourteen years after universal vaccination program launched, challenges remain.
Bloodstream infections may increase risk for MRSA mortality April 2008: Comorbidities, including diabetes and HIV, and increased age also were associated with greater fatality from invasive MRSA.
ED visits for skin, tissue infections on the rise March 2008: Majority of epidemic cases have been mild and are not cause for alarm.
Colombia experiencing an epidemic of cutaneous leishmaniasis February 2008: More children and women are affected as the parasite adapts to new regions; trials are underway for new treatment.
Experts warn of potential dengue fever outbreak in the United States February 2008: David Morens, MD, and Anthony Fauci, MD, caution that dengue fever could pose a significant threat to the continental United States.
One Health Initiative will unite veterinary, human medicine February 2008: Experts urge collaboration between veterinarians, physicians in wake of emerging zoonotic diseases, potential epidemics.
Experts worry dengue outbreak in Puerto Rico could escalate January 2008: Dengue virus serotype 1 has been detected in Puerto Rico for the first time in eight years.
Japanese encephalitis could emerge in North America January 2008

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HIV THERAPY OPTIONS
Postnatal antiretroviral prophylaxis may reduce risk for HIV transmission March 2008: Addition of zidovudine did not improve results over nevirapine alone.

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HIV/AIDS & STDS
CVD increasing in patients with HIV August 2008: Extended survival and ART may put patients with HIV at risk for cardiovascular events.
U.S. Senate passes landmark legislation to fight infectious disease, discrimination August 2008
Vaginal microbicides may prevent infection more effectively in men than women August 2008: Microbicide resistance was predicted using mathematical models.
Initiation of modern HAART led to decrease in drug resistance July 2008: Odds of drug resistance reduced in group of patients receiving boosted protease inhibitors.
Condom distribution program increased availability, acquisition and use June 2008: An increase in distribution with web-based ordering system was observed.
Efavirenz plus two NRTIs may improve virologic efficacy June 2008: Study data highlight the complexity of choosing initial therapy.
Earlier ART may improve HIV clinical outcomes May 2008
Gains and setbacks reported in African HIV testing scale-up efforts May 2008 HIV testing in Africa is a mix of program innovation, funding increases, worker shortages and technological advances.
FDA: Two HIV drugs may be linked with increased coronary risk April 2008
Revised pediatric HIV treatment guidelines released April 2008: New criteria for excluding infection in HIV-exposed infants and children may ease parents’ concerns earlier and make management easier.
Routine HIV testing in EDs linked to increased diagnoses April 2008: Programs were cost effective when compared with the economic and health costs of delayed HIV diagnoses.
Social factors play a role in U.S. HIV/AIDS epidemic among black women April 2008: Risk for HIV is higher among black women than white women, independent of risk behavior.
STDs more common among adolescent girls than previously believed April 2008: Even among girls who reported only one lifetime sex partner, the STD prevalence was 20.4%.
A multifaceted approach may be needed to reduce HIV risk in MSM March 2008: MSM often face a syndemic of psychosocial conditions that may be driving and exacerbating the HIV/AIDS epidemic in this population.
Circumcision of men may decrease STD risk in women March 2008: Male circumcision may not be associated with a reduced risk for HIV acquisition in women.
Scientific barriers render an HIV vaccine unfeasible at present time March 2008: Further efficacy trials may shift funding and focus away from much needed basic science.
HAART associated with decreased pulmonary HIV burden February 2008: HAART may help decrease patients’ susceptibility to other infections.
Methamphetamine prevention programs may overlook many patients at risk for HIV February 2008: Experts say these programs are worthwhile, but the majority of patients who report unsafe sex are not methamphetamine users.
Asian patients may be overlooked for HIV testing January 2008: In Chicago, HIV testing rates lower for residents in Chinatown than in other neighborhoods.
HIV more prevalent among black MSM despite fewer risk behaviors January 2008
HIV/AIDS rate in Washington, D.C. highest among U.S. cities January 2008: Public health officials launch programs to address racial disparity, infant HIV and late diagnosis in wake of grim report on HIV.
Male circumcision may not be a universal HIV prevention tool January 2008: African trials showed male circumcision associated with a 60% reduction in HIV risk, but new studies did not show the same efficacy.

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ISSUES OF RESISTANCE
Communication vital among antimicrobial surveillance programs August 2008: Data sharing and publishing findings can facilitate clinical practice.
Perceptions regarding antibiotic use may require reevaluation August 2008: Risk for antibiotic resistance as an adverse event may be underestimated.

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NOSOCOMIAL INFECTIONS
Patients who carry MRSA may have increased risk for infection, mortality August 2008: Patients with a history of MRSA – as well as those with newly-acquired MRSA – should be targeted for intervention.
Community hospitals often fail to treat MRSA adequately June 2008: In almost half of the hospitals, health care providers did not administer an antimicrobial agent within seven days of infection.
Thorough patient assessments can help determine infection risk June 2008: To reduce the spread of antibiotic-resistant infections in hospitals, patients should be assessed for risk factors during admission.
Tracking the use of antibiotics may help fight resistance June 2008: By determining use patterns, tracking can help health care providers avoid antibiotic overuse.
Carriers as likely to spread MRSA as clinical patients May 2008: Density of nares colonization, decreased patient mobility could predict increased MRSA skin and environmental contamination.
MRSA linked to lower incomes, larger households sizes May 2008: eople with lower median household income were likely to have CA-MRSA on admission.
Predictors for surgical site infections due to MRSA found May 2008: Patients with MRSA surgical site infections were more likely to have Medicare and to be obese.
Risk for VRE linked to previous environmental contamination March 2008: Experts urge increased attention to disinfection in health care settings.
IDSA unveils ‘wish list’ of superbug strategies January 2008: Officials urge federal policymakers to help stop antimicrobial use in food animals and to provide incentives for antimicrobial research.

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VACCINE-PREVENTABLE DISEASES
Pediatric immunization also offers benefits for adults August 2008: The immunization of children helps reduce the spread of infectious diseases by breaking the chain of transmission.
ACIP workgroup recommends adult pneumococcal vaccination updates July 2008: A large number of data have become available since the original recommendations were created in 1997.
CDC recommends herpes zoster vaccine for people aged 60 years and older June 2008: Vaccine was associated with a 64% reduction of shingles in those aged 60 to 69 years.
Measles cases on the rise in U.S. May 2008
Heritable disposition may affect influenza mortality risk February 2008: Risk for influenza death higher among patients who had a close or distant relative who died from influenza.
Mortalities from vaccine-preventable diseases reach an all-time low January 2008

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WHAT'S YOUR DIAGNOSIS?
August 2008

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ZOONOTIC INFECTIONS
Avian influenza: The animal health perspective (Part 3) July 2008
Avian influenza: The animal health perspective (Part 2) June 2008
Avian influenza: The animal health perspective May 2008
Zoonoses transmitted by cats highlight importance of proper care April 2008: CDC’s annual report for 2006 noted 6,940 cases of rabies in wild or domesticated animals, of which 318 were cats.

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